Researchers found that when patients know exactly what drug they are taking, psychedelics perform no better than standard antidepressants in tackling depression. The findings suggest that the clinical advantage of psychedelics might be a product of trial design rather than pharmacologic effect.

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By having a mask that contains the characters following each trigram, our inverted index can be constructed using trigram keys, but we can query it using quadgrams! This already scopes down the potential documents much more than a simple trigram index could.